SrasV1, Main, Exploration, bibRecord, 001603

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Identifieur interne : 001603 ( Main/Exploration ); précédent : 001602; suivant : 001604

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Auteurs : Vineet D. Menachery [États-Unis] ; Amie J. Eisfeld [États-Unis] ; Alexandra Sch Fer [États-Unis] ; Laurence Josset [États-Unis] ; Amy C. Sims [États-Unis] ; Sean Proll [États-Unis] ; Shufang Fan [États-Unis] ; Chengjun Li [États-Unis] ; Gabriele Neumann [États-Unis] ; Susan C. Tilton [États-Unis] ; Jean Chang [États-Unis] ; Lisa E. Gralinski [États-Unis] ; Casey Long [États-Unis] ; Richard Green [États-Unis] ; Christopher M. Williams [États-Unis] ; Jeffrey Weiss [États-Unis] ; Melissa M. Matzke [États-Unis] ; Bobbie-Jo Webb-Robertson [États-Unis] ; Athena A. Schepmoes [États-Unis] ; Anil K. Shukla [États-Unis] ; Thomas O. Metz [États-Unis] ; Richard D. Smith [États-Unis] ; Katrina M. Waters [États-Unis] ; Michael G. Katze ; Yoshihiro Kawaoka [États-Unis] ; Ralph S. Baric [États-Unis]

Source :

mBio [ 2150-7511 ] ; 2014.

RBID : pubmed:24846384

Descripteurs français

English descriptors

KwdEn :
- Animals, Cell Line, Cluster Analysis, Coronavirus (physiology), Coronavirus Infections (genetics), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Gene Expression Profiling, Gene Expression Regulation (drug effects), Histones (metabolism), Host-Pathogen Interactions (genetics), Humans, Influenza A Virus, H5N1 Subtype (physiology), Influenza A virus (physiology), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Interferon Type I, Interferons (metabolism), Interferons (pharmacology), Middle East Respiratory Syndrome Coronavirus (physiology), Models, Biological, Protein Binding, Proteomics, SARS Virus (physiology), Transcription Factors (metabolism), Viral Nonstructural Proteins (metabolism).
MESH :
- chemical , metabolism : Histones, Interferons, Transcription Factors, Viral Nonstructural Proteins.
- drug effects : Gene Expression Regulation.
- genetics : Coronavirus Infections, Host-Pathogen Interactions, Influenza, Human.
- metabolism : Coronavirus Infections, Influenza, Human.
- chemical , pharmacology : Interferons.
- physiology : Coronavirus, Influenza A Virus, H5N1 Subtype, Influenza A virus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Influenza, Human.
- Animals, Cell Line, Cluster Analysis, Gene Expression Profiling, Humans, Interferon Type I, Models, Biological, Protein Binding, Proteomics.

Abstract

The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.

DOI: 10.1128/mBio.01174-14
PubMed: 24846384

Affiliations:

Le document en format XML

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<author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name>
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<author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
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<author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
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<placeName><settlement type="city">Madison (Wisconsin)</settlement>
<region type="state">Wisconsin</region>
</placeName>
<orgName type="university" n="3">Université du Wisconsin à Madison</orgName>
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<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
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<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
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<author><name sortKey="Proll, Sean" sort="Proll, Sean" uniqKey="Proll S" first="Sean" last="Proll">Sean Proll</name>
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<author><name sortKey="Fan, Shufang" sort="Fan, Shufang" uniqKey="Fan S" first="Shufang" last="Fan">Shufang Fan</name>
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<wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
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<author><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name>
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<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
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<settlement type="city">Seattle</settlement>
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<orgName type="university">Université de Washington</orgName>
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<author><name sortKey="Williams, Christopher M" sort="Williams, Christopher M" uniqKey="Williams C" first="Christopher M" last="Williams">Christopher M. Williams</name>
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<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
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<author><name sortKey="Weiss, Jeffrey" sort="Weiss, Jeffrey" uniqKey="Weiss J" first="Jeffrey" last="Weiss">Jeffrey Weiss</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
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<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
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<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
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<author><name sortKey="Webb Robertson, Bobbie Jo" sort="Webb Robertson, Bobbie Jo" uniqKey="Webb Robertson B" first="Bobbie-Jo" last="Webb-Robertson">Bobbie-Jo Webb-Robertson</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Schepmoes, Athena A" sort="Schepmoes, Athena A" uniqKey="Schepmoes A" first="Athena A" last="Schepmoes">Athena A. Schepmoes</name>
<affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Shukla, Anil K" sort="Shukla, Anil K" uniqKey="Shukla A" first="Anil K" last="Shukla">Anil K. Shukla</name>
<affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O" last="Metz">Thomas O. Metz</name>
<affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D" last="Smith">Richard D. Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name>
<affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
</author>
<author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Madison (Wisconsin)</settlement>
<region type="state">Wisconsin</region>
</placeName>
<orgName type="university" n="3">Université du Wisconsin à Madison</orgName>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="1"><nlm:affiliation>Rbaric@email.unc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
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<series><title level="j">mBio</title>
<idno type="eISSN">2150-7511</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cluster Analysis</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (metabolism)</term>
<term>Coronavirus Infections (virology)</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Histones (metabolism)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Humans</term>
<term>Influenza A Virus, H5N1 Subtype (physiology)</term>
<term>Influenza A virus (physiology)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Interferon Type I</term>
<term>Interferons (metabolism)</term>
<term>Interferons (pharmacology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Models, Biological</term>
<term>Protein Binding</term>
<term>Proteomics</term>
<term>SARS Virus (physiology)</term>
<term>Transcription Factors (metabolism)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Animaux</term>
<term>Coronavirus (physiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Histone (métabolisme)</term>
<term>Humains</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (métabolisme)</term>
<term>Infections à coronavirus (virologie)</term>
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<term>Interférons (pharmacologie)</term>
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<term>Lignée cellulaire</term>
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<term>Host-Pathogen Interactions</term>
<term>Influenza, Human</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus Infections</term>
<term>Influenza, Human</term>
</keywords>
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<term>Grippe humaine</term>
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<term>Interférons</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A virus</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>SARS Virus</term>
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<term>Influenza, Human</term>
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<front><div type="abstract" xml:lang="en">The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.</div>
</front>
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<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
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<name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J" last="Eisfeld">Amie J. Eisfeld</name>
<name sortKey="Fan, Shufang" sort="Fan, Shufang" uniqKey="Fan S" first="Shufang" last="Fan">Shufang Fan</name>
<name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name>
<name sortKey="Green, Richard" sort="Green, Richard" uniqKey="Green R" first="Richard" last="Green">Richard Green</name>
<name sortKey="Josset, Laurence" sort="Josset, Laurence" uniqKey="Josset L" first="Laurence" last="Josset">Laurence Josset</name>
<name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
<name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name>
<name sortKey="Long, Casey" sort="Long, Casey" uniqKey="Long C" first="Casey" last="Long">Casey Long</name>
<name sortKey="Matzke, Melissa M" sort="Matzke, Melissa M" uniqKey="Matzke M" first="Melissa M" last="Matzke">Melissa M. Matzke</name>
<name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O" last="Metz">Thomas O. Metz</name>
<name sortKey="Neumann, Gabriele" sort="Neumann, Gabriele" uniqKey="Neumann G" first="Gabriele" last="Neumann">Gabriele Neumann</name>
<name sortKey="Proll, Sean" sort="Proll, Sean" uniqKey="Proll S" first="Sean" last="Proll">Sean Proll</name>
<name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<name sortKey="Schepmoes, Athena A" sort="Schepmoes, Athena A" uniqKey="Schepmoes A" first="Athena A" last="Schepmoes">Athena A. Schepmoes</name>
<name sortKey="Shukla, Anil K" sort="Shukla, Anil K" uniqKey="Shukla A" first="Anil K" last="Shukla">Anil K. Shukla</name>
<name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C" last="Sims">Amy C. Sims</name>
<name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D" last="Smith">Richard D. Smith</name>
<name sortKey="Tilton, Susan C" sort="Tilton, Susan C" uniqKey="Tilton S" first="Susan C" last="Tilton">Susan C. Tilton</name>
<name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name>
<name sortKey="Webb Robertson, Bobbie Jo" sort="Webb Robertson, Bobbie Jo" uniqKey="Webb Robertson B" first="Bobbie-Jo" last="Webb-Robertson">Bobbie-Jo Webb-Robertson</name>
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Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

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